Endocrine & Assay Science

Hypothalamic-Pituitary-Testicular Axis (HPTA) Endocrine Recovery: GnRH Pulsatility, Leydig Cell Steroidogenesis and Clinical SERM Protocols

Neuroendocrine Regulation of the Hypothalamic-Pituitary-Testicular Axis Endogenous androgen homeostasis in the male strength athlete is governed by a tightly regulated, closed-loop neuroendocrine feedback cascade known as the Hypothalamic-Pituitary-Testicular Axis (HPTA).…

Continue ReadingHypothalamic-Pituitary-Testicular Axis (HPTA) Endocrine Recovery: GnRH Pulsatility, Leydig Cell Steroidogenesis and Clinical SERM Protocols

Tendon and Ligament Remodeling Under Supramaximal Loads: Type I/III Collagen Cross-Linking, Somatropin (HGH) and IGF-1 Signaling

Biomechanics of Tendinous Strain Under Supramaximal Barbell Loads During maximal competition squats, bench presses, and deadlifts, human tendons and ligaments act as viscoelastic force transducers that transmit contractile tension from…

Continue ReadingTendon and Ligament Remodeling Under Supramaximal Loads: Type I/III Collagen Cross-Linking, Somatropin (HGH) and IGF-1 Signaling

Endocrine Assay Chemistry in Strength Sports: GC-MS/IRMS Carbon Isotope Ratio Mass Spectrometry, Epitestosterone Ratios and Ester Clearance Half-Lives

Analytical Mass Spectrometry and Urinary Steroid Profiling Clinical and forensic endocrine testing in international strength sports relies upon multi-stage chromatographic separation coupled to high-resolution mass spectrometry to map the human…

Continue ReadingEndocrine Assay Chemistry in Strength Sports: GC-MS/IRMS Carbon Isotope Ratio Mass Spectrometry, Epitestosterone Ratios and Ester Clearance Half-Lives